Category: News
Recap of the 2nd NSC workshop on “SSbD scenarios” on 5 December 2025
Following up from the 1st NSC workshop on “SSbD scenarios for advanced and incremental innovations” (23 June 2025), the NSC Working Group on Safe and Sustainable by Design (SSbD), Innovation & Regulation organised a virtual 2nd NSC workshop on SSbD Scenarios on 5th December 2025. Similarly as the first workshop, this second one was prepared as a collaborative effort among several EU-funded projects: DESIDERATA, PLANETS, SSbD4CheM, and SUNRISE.
The 1st NSC scenarios workshop laid the basis by the description of a scenario by aspects of novelty, exposure, severity, (environmental) sustainability, (economic) scope and immediacy. Case studies enabled a refinement of the scenario description (Wohlleben et al. 2025). The concept of a scenario was integrated by JRC into the revised SSbD Framework, where it serves as a bridge between the SSbD scoping and a tailored safety and sustainability assessment (reproduced in lower figure). It was described as “a specific and real set of conditions (scoping analysis elements) that define the context in which the SSbD assessment is carried out.”(Garmendia Aguirre et al. 2025).
This 2nd NSC scenarios workshop explored how to describe an SSbD scenario, the tailoring rules related, as well as how to select which tailored approach fits best a specific innovation case. Examples of real-world cases were provided by innovators from the projects DESIDERATA, PLANETS, SSbD4CheM, and SUNRISE. In breakout sessions moderated teams went through the respective cases to define the SSbD maturity, pull and push, expected commercial value, probability of success (technical and commercial) and ultimately the return on investment that additional SSbD would expect. Obtained results were compared to six proposedly archetypal SSbD scenarios. This business-focussed algorithm enables defining a tailored SSbD in a more straight-forward manner. Such an approach, based on specifications collected during scoping, could argue for more or less extensive SSbD assessment to be implemented for different innovation cases, providing arguments for innovators in their discussion with management.
Danail Hristozov (GreenDecision, and chair of the NSC WG on SSbD) opened the workshop and welcomed the more than 50 international participants from academia (54%), large industry (17%), SME (9%), consultants (7%), regulators (2%) and EU institutions (9%).
Wendel Wohlleben (BAuA, formerly BASF, and co-chair of the NSC WG on SSbD) presented how to tailor the SSbD implementation by using the scenarios. He explained how the most relevant aspects describing the scenario were selected after the 1st workshop, and how the newly developed spreadsheet “SSbD-ified ECV calculator” estimates the impact of implementing SSbD into an innovation project plan. The standardised business metric of the “Expected Commercial Value (ECV)” was used as the basis for the tool, which had been made available to all workshop participants, and feedback was gathered during the break-out groups.
Workshop participants split up into the break-out groups, where the tailoring and other aspects in the different innovation case were explored and discussed:
- DESIDERATA case study: Olga Thoda, from MONOLITHOS, on geopolymers originating from mining waste as replacement of Aluminum in construction, moderated by Lya Hernandez, RIVM.
- PLANETS case study: Tobias Moss, from Budenheim, on flame retardants in construction, moderated by Carla Caldeira, SYENSQO.
- SSbD4CheM case study: Ondej Panak, from the Slovenian National Institute of Chemistry, on cosmetics (assisted by Assaf Assis, David Barak, and Dror Cohen, from AHAVA Dead Sea Laboratories, moderated by Martin Himly, PLUS.
- SUNRISE case study: María José López Tendero, from Laurentia Technologies, on post-harvest fruit treatment based on safer microencapsulated oil, moderated by Danail Hristozov, GreenDecision.
Martin Himly (PLUS and chair of the NSC WG on ETC) moderated the joint reporting session of the different breakouts, where the discussions in each of the groups were briefly summarised and discussed in the plenary.
Irantzu Garmendia Aguirre from the European Commission’s Joint Research Centre (JRC) contributed key insights to the workshop, sharing the JRC’s perspectives on the current adaptations within the SSbD framework. Her intervention addressed the core SSbD principles, the scoping analysis, and the development of SSbD scenarios, highlighting their relevance for advancing safe and sustainable innovation.
The workshop ended with a final round of feedback and plenary discussion, moderated by Lya Hernández (RIVM), where workshop participants dived into vivid discussions, which will be picked up in the 3rd NSC scenarios workshop anticipated for late spring 2026.
Two main activities are planned as follow-ups of this 2nd workshop: A third workshop (planned for 2026) to discuss the process from archetypal scenarios to tiered SSbD assessment, and a joint peer-reviewed NSC publication about the tailored SSbD approaches followed by the different case studies presented in the workshop.
Workshop materials:
Workshop materials are publicly available in Zenodo, under DOI: 10.5281/zenodo.19554509.
The recording of the workshop is available in the NSC YouTube channel.
References:
- Garmendia Aguirre, I., E. Abbate, G. Bracalente, L. Mancini, G. Cappucci, D. Tosches, K. Rasmussen, B. Sokull-Klüttgen, H. Rauscher and S. Sala (2025). “Safe and Sustainable by Design Chemicals and Materials. Revised framework”. Draft for consultation, can be accessed here.
- Wohlleben, W., C. Caldeira, M. Himly, L. G. Soeteman-Hernández, D. Hristozov and B. Serrano Alfaro (2025). Materials of the NSC workshop on “SSbD scenarios for advanced and incremental innovations” on 23 June 2025. Zenodo. DOI: 10.5281/zenodo.15756156.
- European Commission SSbD Framework
Impressions of the workshop:
SSbD4CheM @ ANTHOS’26
Across three days, the summit created a collaborative platform to exchange knowledge and showcase tools, methodologies, and case studies; discussions highlighted key challenges for SSbD implementation, including limited awareness—particularly among SMEs—data gaps, methodological complexity, and unclear economic incentives. Stakeholders emphasized the need for pragmatic, user-friendly tools, improved data sharing, and stronger links between research, regulation, and industry.
Sessions and roundtables addressed the perspectives of initiators, legislators, regulators, and implementors. A recurring message was the importance of shifting from reactive compliance to proactive, design-led innovation. Solutions presented by EU projects demonstrated how digital tools, AI, tiered assessment strategies, and life-cycle thinking can support early-stage decision-making and reduce risks and costs.
The summit also underlined the importance of regulatory preparedness, trusted environments, and cross-sector collaboration. Concepts such as regulatory sandboxes, standardized data formats, and the role of SSbD ambassadors emerged as key enablers for wider adoption.
ANTHOS’26 concluded with a forward-looking discussion stressing the need for incentives, education, and coordinated action to scale SSbD. The event successfully strengthened collaboration across the community and set the stage for future innovation in safe and sustainable materials.
SSbD4CheM had a very active role in the conference:
- Several partners were involved in the Organising Committee (Andreas Falk, Beatriz Alfaro (BNN), Milica Velimirovic (VITO), Ivana Burzic (WOOD K plus)),
- and in the Scientific Committee (Andreas Falk, Milica Velimirovic, Ivana Burzic).
- Andreas Falk, Antje Biesemaier (LIST) and Barry Hardy (EwC) reviewed the poster abstracts.
- BNN (Andreas Falk) was the main moderator of the conference.
- Andreas Falk was speaker and panellist in the Solutions Session 2 (Legislators) representing the NSC.
- Milica Velimirovic was Co-chair of the Solutions Session 4 (Scientific Implementators).
- The project roll up was exposed all throught the conference in the projects area, next to the SSbD4CheM booth.
- Oral presentations:
- Milica presented the project in the BioNanoNet Networking event. DOI: 10.5281/zenodo.19550468.
- Yvonne Kohl (Fraunhofer) supported Pamina Weber (LIST) to prepare presentation in Session 4 (scie. Implementors) – “Bridging in silico, in chemico, in vitro assessments for SSbD-driven advanced materials and chemicals innovation – where do we stand – what is next – what can we reach?“, presented by Ivana Burzic. DOI: 10.5281/zenodo.19628304.
- Barry Hardy gave an oral presentation in the Solutions Session 3 (Regulators), about in silico methods and AI developments, presenting the goals of the project with regulatory acceptance. DOI: 105281.zenodo.19389773.
- Posters:
- Ondrej Panak (NIC) in collaboration with AHAVA had a poster on the cosmetic CS, entitled “SSbD Assisted Implementation of Nanocellulose Additives in Skin Care Products“. DOI: 10.5281/zenodo.19368571.
- LIST/Fraunhofer (Antje Biesemeier, Yvonne Kohl) had a poster on CNC characterisation in vitro experiments, entitled “Multimodal characterization of the safety and sustainability of cellulose nanoparticles in 2D and 3D in vitro model“. DOI: 10.5281/zenodo.19368540.
- Florian Meier (Postnova) had a poster on CNC characterization ,entitled “A multi-analytical approach for guiding the safe and sustainable use of cellulose nanomaterials“. DOI: 10.5281/zenodo.19367261.
- KORTEKS (Onur Celen and Mine Turkay) had a poster on “Advancing Safe and Sustainable Textile Materials in the SSbD4CheM Project: Industrial Production of Virgin PET, Recycled PET (r -PET) and Bio-Based PLA Yarns“, that was presented by Ondrej. DOI: 10.5281/zenodo.19470863.
- Additionally Florian, Ondrej presented their posters in the Poster Pitch Session
- The project also had a booth, sponsored by WOOD K plus, were we were able to showcase different prototypes developed in the frame of SSbD4CheM project – Visitors were super interested:
- Automotive interior parts manufactured using novel Wood Plastic Composites (WPCs) with optimised emissions and odor (Wood K plus).
- PFAS free water repellent and antimicrobial coated textile (Wood K plus, Novex, and KORTEKS).
- High-sensitivity light scattering detector for cellulose nanomaterials’ characterization (Postnova).
- Nanocellulose as sustainable additive being applied in different AHAVA cosmetic products (SPF lotions, facial creams, facial mud mask) serving for different functionalities (AHAVA, NIC).
The SSbD4CheM Knowledge Sharing Platform: Turning Safe and Sustainable by Design into Practice
The transition to safer and more sustainable chemicals and materials requires more than good intentions — it needs accessible knowledge, practical tools, and shared understanding across disciplines. This is exactly the main aim of the EU-funded project SSbD4CheM project. The project is developing the SSbD4CheM Knowledge Sharing Platform, a centralized, web-based infrastructure that offers tools, data, guidance, and training to support the implementation of the SSbD framework for chemicals and AdMa, as elaborated by the EC Joint Research Centre (JRC), and help stakeholders (researchers, industry, policymakers, etc.) translate the SSbD principles into real-world decision-making throughout their innovation processes.
The platform brings together a wide range of tools, data resources, methodologies, and guidance materials relevant to SSbD. Instead of navigating multiple disconnected sources, users can access structured information that supports safety and sustainability considerations from the earliest design stages through to assessment and evaluation. One of the platform’s key functions is to enable structured SSbD assessment workflows. Users can explore digital tools that support hazard screening, sustainability evaluation, and life-cycle thinking, helping them document and compare design choices in a transparent and reproducible way.
Beyond tools and data, the Knowledge Sharing Platform also serves as a learning environment. It provides access to training materials, guidance documents, and explanatory resources that help users understand SSbD concepts, methodologies, and regulatory contexts — supporting capacity building across sectors and disciplines.
In line with EU best practices, the platform promotes FAIR principles (Findable, Accessible, Interoperable, Reusable), ensuring that data and resources hosted or linked through the platform can be more easily discovered, reused, and integrated into other tools, projects, and innovation processes.
Through the platform, users can access different tools that allow them to perform risk assessment, SSbD scoring, generate reports, and use knowledge infrastructure and databases for integrated, safer, and sustainable-by-design workflows. By the beginning of January 2026, the platform contains following resources:
- Risk Assessment Report – Case Study: This report is generated by the SSbD4CheM integrated assessment tool designed to support safe and sustainable innovation across sectors such as cosmetics, textiles, and automotive.
- SmartSafety – Chemical Risk Calculation Tool: Software that streamlines safety assessments by integrating product data and supporting health and environmental evaluations.
- ASPA-assist: Web-based graphical interface which guides users through the steps and decisions involved in applying the SSbD process.
- ToxTemp: Web-based tool and database designed to document methods by supporting various readiness levels to ensure method evaluation and transparency.
- ACCORDs KI: Platform for accessing and submitting research protocols, experimental data, and images, offering standardised upload templates and a materials characterisation toolbox.
- SDS collector/extractor: Tool that allows users to search, download, and extract structured data from SDS using CAS numbers or IUPAC names, exporting the information in CSV format.
- PubMed ChemInsight: To accelerate literature discovery on chemicals and biological targets with smart search, synonym expansion, and automated result delivery.
- PubChemPal: Interactive, user-friendly application that enables scientists, researchers, and regulatory professionals to retrieve, clean, and explore structured PubChem compound data using CAS numbers or PubChem CIDs.
- ECHA database and notebooks: Provides access to chemical safety data and organized documentation (e.g. Chemical similarity search on RDT studies from REACH database, Repeated dose toxicity studies from reach database, EdelweissData dataset for CLP classifications, EdelweissData dataset for ecotoxicological endpoints)
- Protocols area – guidance and database: Database of in silico and in vitro protocols used throughout the project, providing standardized methods and guidance.
- Data area – guidance and access: Guidance page for information on data management
SSbD4CheM Protocol Database with uploaded protocols
The SSbD4CheM Knowledge Sharing Platform is designed as a collaborative space. By connecting tools, knowledge, and stakeholders, it supports dialogue and exchange between scientists, innovators, regulators, and sustainability experts working toward the same goal: chemicals and materials that are safe and sustainable by design. It is a practical enabler for embedding SSbD thinking into chemical and material innovation, helping turn policy ambitions into actionable, science-based practice.
Explore now the SSbD4CheM Knowledge Sharing Platform here.
WP Leaders interview series: Barry Hardy (EwC)
Barry Hardy is CEO of Edelweiss Connect (Switzerland). Within SSbD4CheM, he is leading the work package dealing with the project SSbD framework and workflow.
Tell us a bit about yourself. What is your area of expertise?
Barry Hardy: I am Founder and CEO of Edelweiss Connect, working at the intersection of computational toxicology, FAIR data infrastructure, and Safe and Sustainable by Design (SSbD) innovation. Our expertise focuses on developing knowledge infrastructures and mechanistically interpretable modeling workflows that integrate experimental and computational evidence to support predictive safety assessment. This includes development of FAIR-compliant data frameworks, AOP-based mechanistic modeling, and AI-assisted workflows such as ASPA, designed to generate high-quality, traceable evidence suitable for industrial decision-making and future regulatory acceptance.
How does your specific work package “SSbD4CheM framework and workflow” contribute to the project?
BH: Our work package contributes by developing the SSbD framework implementation layer that connects FAIR data, mechanistic knowledge infrastructure, and industrial innovation workflows. We are extending ASPA workflows to support SSbD applications, enabling structured integration of experimental data, mechanistic pathway knowledge, and predictive models into reproducible evidence packages. This infrastructure ensures that safety and sustainability assessments are transparent, traceable, and reusable, supporting industrial partners in making informed design decisions and preparing evidence that can ultimately support regulatory evaluation and acceptance.
What is the most exciting thing about the activities in your work package?
BH: The most exciting aspect is enabling a transition from fragmented data and isolated experiments to integrated, mechanistically grounded evidence that can directly guide safer and more sustainable chemical and material design. By combining FAIR data principles, knowledge graphs, and mechanistic modeling workflows, we are creating a foundation where safety and sustainability can be evaluated predictively and early in innovation. This opens the door to faster, more reliable development of safer products while building confidence in new approach methodologies (NAMs) that can eventually replace animal testing and support regulatory transformation.

- Barry Hardy
CEO at Edelweiss Connect and Founder of SaferWorldbyDesign“By integrating FAIR data, mechanistic knowledge, and AI-assisted workflows, we are transforming fragmented scientific evidence into predictive, transparent, and reusable knowledge—empowering industry to design safer and more sustainable chemicals and materials from the earliest stages of innovation, while building the foundation for future regulatory acceptance.”
From your point of view, who can benefit the most from the project?
BH: Industrial innovators and product developers will benefit significantly by gaining tools and frameworks that allow them to design safer and more sustainable chemicals and materials more efficiently and with greater confidence. At the same time, regulators and the broader scientific community will benefit from access to structured, high-quality, and reproducible evidence that supports transparent safety and sustainability assessment. Ultimately, society as a whole benefits through safer products, reduced environmental impact, and accelerated adoption of innovative, human-relevant methods for safety evaluation.
Read through this powerful reflection poem from Barry Hardy, on humanity standing at a crossroads, armed with powerful intelligence and technology yet risking ecological collapse, social fragmentation, and moral drift if wisdom and empathy do not guide action. It calls for stewardship, compassionate AI, cultural renewal, and collective responsibility to consciously design a safer, more humane world while there is still time.
SSbD4CheM at SETAC North America 46th Annual Meeting (16-20.11.2025, Portland)
SSbD4CheM was represented at the SETAC North America 46th Annual Meeting, one of the leading international conferences dedicated to environmental science, toxicology, and sustainable solutions in environmental chemistry.
Organised by the Society of Environmental Toxicology and Chemistry (SETAC), the annual meeting gathered from 16-20 November 2025 in Portland (Oregon) more than 1.500 participants from research institutions, international organisations, regulatory bodies, local and national authorities, regional stakeholders, and end-user communities from across the world.
During the event, Connor Hardy from Edelweiss Connect, partner of the SSbD4CheM project, presented a poster entitled “Hazard profiling and characterisation supporting Safe and Sustainable by Design Workflows applied to chemicals and materials”. The presentation highlighted the project’s objectives, ongoing activities, and recent progress in supporting Safe and Sustainable by Design (SSbD) approaches for chemicals and materials.
Participation in the conference provided an excellent opportunity to promote the SSbD4CheM project within the North American SETAC community, while also fostering networking and exchange with researchers, policymakers, and industry representatives working towards safer and more sustainable chemical innovation.
SSbD4CheM General Assembly M24
On 15th December 2025, the SSbD4CheM consortium came together virtually for the M24 General Assembly. The meeting provided an opportunity to review the progress achieved over the past six months and to align on priorities and next steps for the months ahead.
Partners presented updates across the project’s Work Packages, highlighting key scientific and technical advances. Presentations were delivered by WP leaders (Milica Velimirovic, Beatriz Alfaro Serrano, Ivana Burzic, Barry Hardy, Tassos Papadiamantis/Panagiotis Kolokathis, Stephan Wagner, Yvonne Kohl, Wouter Gebbink, and Fruela Pérez Sánchez). A dedicated session also focused on the progress of the internal case studies in the automotive, textiles, and cosmetics sectors.
We were pleased to have some members of the External Advisory Board (EAB) joining us — Melanie MacGregor, Linda J. Johnston, Matteo Zanotti Russo, and Dr. Ze’evi Ma’or — and we sincerely thank them for their continued support and valuable guidance on project developments.
As always, it was a pleasure to connect with all partners and to continue working together towards the goals of SSbD4CheM.
SSbD4CheM @ G4F Scientific Day
On 4–5 December 2025, SSbD4CheM participated in the G4F Scientific Day – Environment & Health, held in Brussels and dedicated to the theme “Field-Flow Fractionation (FFF): pharmaceutical and environmental applications.” The two-day event gathered an international audience and offered a rich programme featuring 2 keynote lectures, 7 scientific talks, 2 interactive workshops, and multiple networking opportunities. In total, around 20 participants from across Europe took part.
Representing the SSbD4CheM project, Dr. Milica Velimirović Fanfani (VITO) contributed to the scientific programme with her presentation, “Holistic Nanoplastics Analysis: The Role of Field-Flow Fractionation in a Comprehensive Multimethod Framework.” Her talk highlighted the importance of FFF in characterising complex nanoplastic mixtures and demonstrated how multimethod approaches can enhance analytical robustness—key elements in advancing safe and sustainable materials assessment.
Throughout the event, Dr. Velimirović Fanfani also engaged in discussions exploring collaboration opportunities with other European researchers and stakeholders, further strengthening SSbD4CheM’s international outreach.
Agenda available here.
SSbD4CheM @ BelTox–BEMS Annual Meeting 2025
On 4 December 2025, the SSbD4CheM project took part in the BelTox–BEMS Annual Meeting 2025, hosted at Sciensano in Brussels. This year’s edition, “Unmasking Microplastics: Impacts, Challenges and Implications for (Eco)Toxicology,” brought together around 100 participants researchers (academia and industry) to explore one of today’s most rapidly evolving topics in environmental and human health research.
Co-organised once again by the Belgian Society of Toxicology and Ecotoxicology (BelTox) and the Belgian Environmental Mutagen Society (BEMS), the meeting offered a comprehensive overview of the microplastics landscape. Participants were introduced to key concepts in microplastics research and learned about state-of-the-art analytical methods—including Pyr-GC/MS coupled with sp-ICP/MS and advanced microscopy techniques. The programme also highlighted the presence and effects of microplastics in agricultural soils and showcased interdisciplinary progress spanning ecotoxicology, analytics, and human health.
The event further addressed toxicity assessment using in vivo and alternative models and examined persistent challenges in risk assessment, such as data quality and knowledge gaps regarding health impacts. Mitigation strategies, insights from EU-funded research, and the Young Scientists Competition enriched the day through discussion, innovation, and networking.
Representing SSbD4CheM, Dr. Milica Velimirović Fanfani (VITO) contributed to the scientific programme with her presentation, “Low µm-range microplastics and nanoplastics: finding the needle in the haystack”. Her participation also fostered national outreach and opened discussions on potential collaboration opportunities within Belgium’s growing microplastics research community.
SSbD4CheM @ GSRS25
The 15th Global Summit on Regulatory Science 2025 (GSRS25) took place from 15–17 September 2025 in Lausanne, Switzerland. This year’s conference brought together more than 200 scientists to exchange their experiences and insights on the use of digital tools and artificial intelligence in regulatory science, for building a strong regulatory science with tomorrow’s technologies.
Representing the SSbD4CheM project, Barry Hardy (Edelweiss Connect) presented a poster showcasing the project’s work on developing a robust knowledge infrastructure. The poster, titled “FAIR Knowledge Infrastructure for Next Generation Risk Assessment and Safe and Sustainable by Design Workflows: Enabling High-Integrity Evidence Generation for Regulatory Submissions Including New Approach Method Results”, highlighted how FAIR data principles can support next-generation risk assessment and Safe and Sustainable by Design approaches. The poster introduced a FAIR knowledge infrastructure that integrates NAMs data, mechanistic insights, and harmonized workflows to generate transparent, traceable, and regulatory-grade evidence. It supports NGRA and SSbD through knowledge graphs, standardized data, and AI-ready structures, enabling robust assessments, improved data reuse, and compliance with evolving regulatory expectations.
The participation in GSRS25 offered an excellent opportunity to engage with regulatory scientists and foster new interactions relevant to the project’s goals.
The poster programme is available here.





















































